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Goals
Functional Genomics Technology
- Generate sets of full-length cDNA clones and sequences that represent human genes and
model organisms.
- Support research on methods for studying functions of nonprotein-coding sequences.
- Develop technology for comprehensive analysis of gene expression.
- Improve methods for genome-wide mutagenesis.
- Develop technology for large-scale protein analyses.
Comparative Genomics
- Complete the sequence of the roundworm C. elegans genome by 1998.
- Complete the sequence of the fruitfly Drosophila genome by 2002.
- Develop an integrated physical and genetic map for the mouse, generate
additional mouse cDNA resources, and complete the sequence of the mouse genome
by 2008.
- Identify other useful model organisms and support appropriate genomic studies.
Efficient interpretation of the functions of human genes
and other DNA sequences requires that resources and strategies be developed to
enable large-scale investigations across whole genomes. A technically challenging
first priority is to generate complete sets of full-length cDNA clones and sequences
for human and model-organism genes. Other functional-genomics goals include studies
into gene expression and control, creation of mutations that cause loss or alteration
of function in nonhuman organisms, and development of experimental and computational
methods for protein analyses.
Comparative Genomics
The functions of human genes and other DNA regions often are revealed
by studying their parallels in nonhumans. To enable such comparisons,
HGP researchers have obtained complete genomic sequences for the bacterium
Escherichia coli, the yeast Saccharomyces cerevisiae, the
roundworm Caenorhabditis elegans, the fruitfly Drosophila melanogaster,
the laboratory mouse, and many other organisms. The availability of complete
genome sequences generated both inside and outside the HGP is driving
a major breakthrough in fundamental biology as scientists compare entire
genomes to gain new insights into evolutionary, biochemical, genetic,
metabolic, and physiological pathways. HGP planners stress the need for
a sustainable sequencing capacity to facilitate future comparisons.
Text adapted from F. Collins, Ari Patrinos, et al., "New Goals for
the U.S. Human Genome Project: 1998-2003," Science 282:
682-689 (1998). See HGP
Goals for more details.
U.S. Department of Energy and National Institutes of Health Guidance
- Functional
Genomics abstracts from 2002 U.S. DOE Human Genome Program Contractor-Grantee
Workshop IX
- Functional
Genomics abstracts from 2000 U.S. DOE Human Genome Program Contractor-Grantee
Workshop VIII
- Functional Genomics abstracts
from the 1999 U.S. DOE Human Genome Program Contractor-Grantee Workshop
VII
- Abstracts
from Beyond the Identification of Transcribed Sequences: Functional
and Expression Analysis 10th Annual Workshop October 28 through
October 31, 2000
- Abstracts
from Beyond the Identification of Transcribed Sequences: Functional
and Expression Analysis 9th Annual Workshop, October 28-31, 1999
- Abstracts
from Identification of Transcribed Sequences: Functional and
Expression Analysis: November 1997
- Abstracts
from 6th International Workshop on the Identification of Transcribed
Sequences October 3-5, 1996
- U.S. NIH NHGRI
Database of research projects
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