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Imaging Biological Structures
Because molecular shape often provides clues to function in biological systems,
obtaining a detailed knowledge of structure can help elucidate the basic
principles of cell and organism function and the role of faulty structures
in disease. A broad collection of structural data will provide valuable
information beyond that available from individual structures and will have
applications in the life sciences, biotechnology, and medicine.
Key advances making structural genomics research possible include the availability of synchrotrons and
high-field NMR (nuclear magnetic resonance) instruments; the MAD (multiwavelength anomalous
diffraction) method of phase determination; high-throughput cloning and recombinant expression; a flood
of information from genome sequencing projects; and bioinformatics methods for protein-fold assignment,
model building, and function prediction.
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