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Genome Tools and Technologies
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Lab on a Chip
Microarrays
Gene Chips Reveal Susceptibilities
Computer with Sequence Trace
Understanding Gene Function
Mouse-Human Homologies
Next Generation Sequencing Technologies
JGI Sequencing Facility
IBM SP Supercomputer
NERSC-Enabled Accomplishments
Spallation Neutron Source
Mass Spectrometer
Natl. Synchrotron Light Source
NMR Spectrometer
Advanced Light Source
Advanced Photon Source
Human Mammary Cell
FISH Mapping of DNA Fibers
FISHing for Genes
Chromosome Paints
Telomere Staining
Mapping Chromosome 16
Cutting DNA w/Restriction Enzymes
Cloning DNA in Plasmids
Overlapping Clone Library

Computer Screen with Sequence Trace

image credit: U.S. Department of Energy Human Genome Program, http://www.ornl.gov/hgmis.

caption: Massive quantities of genomic data and high-throughput technologies are now enabling studies on a vastly larger scale than ever before, for example, in monitoring and comparing the activity of tens of thousands of genes simultaneously in cancerous and noncancerous tissue. Advanced computational tools and interdisciplinary experts are needed to capture, represent, store, integrate, distribute, and analyze all the data.

Bioinformatics is the term coined for the new field that merges biology, computer science, and information technology to manage and analyze the data, with the ultimate goal of understanding and modeling living systems. Computing and information demands will continue to rise with the explosive torrent of data from large-scale studies at the molecular, cellular, and whole-organism levels.

For more on the science behind the Human Genome Project, see our Website.

This image originally appeared in the 1992 U.S. DOE Primer on Molecular Genetics.

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This image gallery is a special feature of the U.S. Department of Energy's Human Genome Project Information and Genomes to Life Web sites.